By Loren Pickart, PhD
GHK and DNA: RESETTING THE HUMAN GENES FOR HEALTH
This information is for the use of medical researchers. It must be emphasized that GHK and other copper binding peptides have not been tested and approved for the treatment of human diseases.
The primary cause of human aging and its attendant diseases are changes in the activity of the human genome. During aging there is an increase in the activity of inflammatory, cancer promoting, and tissue destructive genes plus a decrease in the activity of regenerative and reparative genes.
Regenerative copper peptides appear to help maintain wellness and youth. The human peptide GHK induces a plethora of health associated actions such as tissue repair, anti-inflammatory actions, anti-cancer effects, anti-infection, stem cell activation, increasing protein P63, and so on. Gene data from the Broad Institute indicates that GHK controls or strongly influences 31.8% of the human genes - increasing the output in 59%, and reducing it in 41%, of the genes.
In 2010, The Broad's Connectivity Map predicted that GHK, at a low and non-toxic level, would reverse the effects of aggressive, metastatic human colon cancer on 38 critical cancer-spreading genes. Specifically, it found that the cancer was suppressing genes used to kill cancer cells; the programmed cell death apoptosis system. Cells have "checkpoints" to determine if DNA is made properly and if it is not, the programmed cell death system terminates the cell. Recently, it was found that GHK did not harm certain normal cells, but acted reset the programmed cell death in human cancer cells and inhibit their growth. GHK-Cancer
In 2012, the Connectivity Map indicated that GHK would shift the gene output in severe emphysema in chronic obstructive lung disease (COPD) and shut down tissue destructive genes while increasing the output of genes associated with tissue healing and remodeling. This prediction was confirmed when tested on cells from patients with the disease where GHK, at a very low and non-toxic level, shifted the cellular genes patterns from tissue destruction to tissue repair. GHK-Emphysema
The Holy Grail of genome research is resetting the genes for health. GHK appears to do this on a wide range of tissues and diseases. Since GHK was originally isolated as a factor high in young persons but that declines with age, it is also possible that the molecule might restore humans to a biologically younger state.