New Article!
Needling and Rollers for Scar Reduction by Dr. Phillipa McCaffery

Visit Our NEW Unified Website at ReverseSkinAging.com

Folligen Solution Therapy Spray®
8 ounces for $36.95 (3 month supply!)

Compare to Tricomin Solution Follicle Therapy Spray®
6 ounces for $48.00.
Folligen Solution has more than 31.8 times more breakdown-resistant,
Long-acting, High-Potency Copper-Peptides
Per ounce and No Blue Dyes!
(Source - Evergreen Analytical Labs, Redmond, WA)

Compare to Concentrated Graftcyte Solution®
5.7 ounces for $125.00.
Folligen Solution has 9.0 times more breakdown-resistant, long-acting, high-potency Copper-Peptides per ounce!
(Source - Evergreen Analytical Labs, Redmond, WA)

Click here to compare US patents on Folligen vs GraftCyte® and Tricomin®.
 
 

Folligen for Hair Retention and Hair Regrowth

Sections in this page:
Folligen Lotion, Folligen Cream and Folligen Solution Therapy Spray
How to Order Hair Products
Ingredients
Copper-Peptides and Hair Growth
Is Copper Better Than Propecia® for Blocking DHT?
Advantages of Folligen Over Other Copper-Peptides
Calming Actions of Folligen on an Irritated Scalp
Too much zinc may damage your hair and speed aging in your body
References

Folligen® is recommended by nutrition expert Will Brink in Muscle Magazine International. See his article "Hair Today, Gone Tomorrow" from Musclemag International at www.brinkzone.com/hair.html

From Greg Chambers "Hair Loss Newsletter" -  "One of the great unsung heroes in the fight against hair loss, Folligen, is available relatively cheaply and one of the few creams effective on the front of the of the head (in some cases, nothing works 100 percent for everyone). It uses Copper-Peptide technology from the inventor of th

What is Folligen and What Does It Do?

Folligen is a non-drug product designed to improve scalp and hair follicle health and hair vitality. Folligen had its beginning as a skin repair cream that was being tested in the Dermatology Department at the University of California at San Francisco. A 41-year-old woman with severe hair loss tried one of our skin repair creams because nothing else had worked to restore her lost hair. In two and one-half months she regained all of her lost hair. Other people began using our skin repair cream to counter hair loss and in time, Folligen emerged as a distinct product.

Folligen's biological effect on hair is similar to, but more effective than, other Copper-Peptide products such as Graftcyte and Tricomin which are skin repair products that aid hair growth and scalp health.

Rigorous testing by leading dermatologists. Skin Biology's skin renewal products have been proven effective after rigorous testing by leading dermatologists. Results of clinical studies on the the skin regeneration and anti-irritant actions of our products have been published in international dermatology journals. No cosmetic skin renewal products on the market have this level of independent published evidence of effectiveness. Clinical and Safety Studies on Products

Folligen® is a non-drug product designed by Dr. Loren Pickart to improve scalp and hair follicle health and hair vitality. Folligen is especially useful in helping to reduce scalp irritation caused by other hair growth products such as Rogaine® (minoxidil), Retin-A® (retinoic acid) and Propecia®. Compare Folligen Cream or Folligen Lotion at $19.95 and Folligen Solution Therapy Spray (8oz) for $36.95 to Tricomin Solution Follicle Spray (6oz) by ProCyte for $48.00 and GraftCyte Solution® 5.7oz) for $125.00 which are products based on Dr. Pickart's earlier hair health inventions. Click here to compare US patents on Folligen vs GraftCyte® and Tricomin®.

Folligen Solution has 9.0 times more copper peptides per ounce than Concentrated Graftcyte®  and 31.8 times more copper peptides per ounce than Tricomin® (Source - Evergreen Analytical Labs, Redmond, WA).

All Folligen products contain a high concentration of blue-colored copper-peptide complexes and do not contain any blue dyes or scalp damaging detergents or alcohol. Tricomin contains blue dyes to give the impression of more copper-peptide complexes. Folligen Solution Therapy Spray uses small amounts of polysorbate 20 and propylene glycol to enhance the uptake of copper-peptide around the hair follicle.

Folligen Lotion is used to restore scalp health and normal hair growth after dyes, permanent waving and hair straighteners. Visit Hair Damaged by Relaxers and Perms

Folligen Cream, Folligen Lotion, Folligen Solution Therapy Spray, Emu Oil 

Product	Order
Folligen Lotion or Cream Copper-peptide scalp cream to improve scalp health, follicle health and hair vitality. Best for use within areas of existing but thinning hair. 45 to 60 day supply  2oz $21.95
Folligen Solution Therapy Spray Combo 8oz fine-mist spray bottle plus 2oz spray bottle $40.95
Folligen Therapy Spray 2oz or 8oz - from $10.00
Hair Regrowth System for Women 2oz Folligen Lotion or Cream and 2 oz 2% Minoxidil for Women $32.95 - Note: Please thoroughly research all precautions on Minoxidil before purchasing this product.
Minoxidil for Women and for Men The manufacturer of minoxidil only recommends the 2% minoxidil for women - 5% for men.  Note: Please thoroughly research all precautions on Minoxidil before purchasing this product.
Hair Regrowth System For Men 2oz tube Folligen Lotion or Cream and 2oz of 5% Minoxidil for Men $33.95 This 5% minoxidil is only recommended for men - Note: Please thoroughly research all precautions on Minoxidil before purchasing this product.
Folligen Therapy Conditioner Very mild and highly protective conditioner to add slip and luster to your hair.  8oz $19.95
Folligen Shampoo/Conditioner Combo 8oz of each $33.95
Folligen Total Combo Trial Pack Test all Folligen products. Contains Folligen Spray 2 oz, Folligen Cream 1/4 oz, Folligen Lotion 1/4 oz, Emu Oil for Hair, Folligen Shampoo 2 oz and Folligen Conditioner 2oz.  $25.95
Sample Pack - Folligen Cream, Folligen Lotion, Emu Oil for Hair 1/4 oz each - $11.00
Sample Pack - Folligen Cream, Folligen Lotion, Emu Oil for Hair, Folligen Spray - 1/4 oz of Folligen Cream, Folligen Lotion, and Emu Oil for Hair, 2 oz of Folligen Spray - $19.95

Important: Please set your browser security to "Medium". A setting of "High" will not work with the secure credit card encryption system.

If you forget your password or User ID, please go to MyExpressCheckout FAQ

Note: Copper-peptides are formed when a solution of the hydrolyzed soy protein is mixed with copper chloride. Less than 1 in 10 trillion of the copper chloride molecules remains as copper chloride.

Folligen Lotion
The Lotion is a more liquid version of the cream. Works better in denser hair areas. Good results reported for scalp and hair recovery after permanent waving and hair straightening procedures.
Product Ingredients: Purified water, squalane, octyl palmitate, PEG-100 stearate (glycerol stearate + PEG-100 stearate), cetyl alcohol, copper peptides (hydrolyzed soy protein and copper chloride), stearic acid, saw palmetto oil, allantoin, polypropylene glycol, diazolinydinyl urea, methylparaben, propylparaben, herbal fragrance, tocopheryl acetate, retinyl palmitate, ergocalciferol.

Folligen Cream
The cream works well on hairlines.
Product Ingredients: Purified water, squalane, octyl palmitate, PEG-100 stearate (glycerol stearate + PEG-100 stearate), cetyl alcohol, copper peptides (hydrolyzed soy protein and copper chloride), stearic acid, saw palmetto oil, allantoin, polypropylene glycol, diazolinydinyl urea, methylparaben, propylparaben, herbal fragrance, tocopheryl acetate, retinyl palmitate, ergocalciferol.

Folligen Solution Therapy Spray
This water-based Folligen comes with a sprayer for application.
Product Ingredients: Purified water, aloe vera gel, copper peptides (hydrolyzed soy protein and copper chloride), glycerin, propylene glycol, polysorbate-20, allantoin, diazolinydinyl urea, methylparaben, propylparaben, herbal fragrance.

Skin Biology's new and patented copper peptide technology is Dr. Pickart's most effective copper peptide system to date. These breakdown-resistant, improved copper peptides give a longer-acting and stronger skin regeneration and also can be used with hydroxy acids and Retin-A. The single peptides (tripeptides or pentapeptides) used in many products are fragile, short-acting, and cannot be used with hydroxy acids. Extensive safety testing has proven Skin Biology's copper peptides to be nonallergenic and none irritating. Skin Biology's copper peptides have neither the allergenic sensitization problems of the bacterial produced copper peptides nor the biological inactivity ("colorless-copper") of copper complexes used by some irresponsible cosmetic companies.

For specific recommendations for various hair needs, visit the following pages:

Folligen for Men

Folligen Therapy Shampoo and Conditioner

Hair Damaged by Relaxers and Perms

Skin Repair after Hair Removal (Waxing, Electrolysis, Lasers)

Copper-Peptides after Hair Transplants

New! - Emu Oil S Lipid Replenisher for Hair

Folligen was designed by Dr. Loren Pickart whose previous inventions have produced clinically-proven products for the hair and scalp health such as products for hair transplantation sold as the GraftCyte® Advanced Hair Restoration Technology for improving the success of  hair transplants consisting of: GraftCyte® Moist Dressings, GraftCyte® Hydrating Mist, GraftCyte® Post-Surgical Shampoo & Conditioner, and GraftCyte® Head Start Single Patient Pack, and the Tricomin system for treatment of thinning hair consisting of the Tricomin® Solution Follicle Therapy Spray, Tricomin® Revitalizing Shampoo, Tricomin® Restructuring Conditioner and Tricomin® Conditioning Shampoo. Three US Patents 5,382,431; 5,554,375; 5,698,184 have issued on this technology which strongly assists skin renewal and hair follicle regeneration. For more details about this approach see Copper Peptide Regeneration .

Advising Skin Biology on hair growth methods is Prof. Hideo Uno, one the the world's leading researchers on hair growth. Dr. Uno conducted much of the early work on Rogaine (minoxidil) and wrote the standard monograph on Rogaine that was distributed by Upjohn Pharmaceuticals.

Copper-Peptides and Hair Growth

Copper ion complexed with certain peptides has both skin repair and hair growth enhancement effects. Examples of this are Folligen (from Skin Biology) and Tricomin and GraftCyte (from ProCyte Corporation).

The skin of the mouse to the left was shaved, then treated in three spots with Folligen. The result is a much more rapid hair growth (the three circular patches of hair) in the three spots treated with Folligen. While human hair growth will not respond nearly as dramatically as in mice, skin health and hair follicle function are closely interrelated. New skin appears to arise from the hair follicle. As a person ages, our hair follicles get smaller, producing thinner hair shafts. The blood circulation system that supplies nutrients and oxygen to the hair follicle send fewer blood vessels to the hair follicle, thus inhibiting the vital flow of nutrients to the hair follicle. Copper-peptide complexes improve skin health and a more healthy skin increases the blood vessel network to the hair follicles resulting in larger follicles that grow hair faster with thicker hair shafts.

In the microscopic images to the left, the magnifications are identical. The top photo is mouse skin untreated with copper-peptides. The bottom photo is mouse skin treated with copper-peptides. Note the larger hair follicles (the elongated purple columns) in the lower photo, the increased content of subcutaneous fat in the skin (the white material in the center of the skin), and the increased thickness of the skin. When we are young, we have a layer of fat under the skin (part of "baby fat") which is greatly reduced as we age. Hair researchers have noted the accumulation of this fat around healthy follicles that are vigorously growing hair, and its relative lack in around dormant follicles, and have postulated that these cells serve a supportive function for the hair follicle. In animal studies, copper peptides have reduced or stopped the hair loss associated with chemotherapy for cancer. It must be emphasized that effects in in humans on hair follicle health are not as dramatic.

How Biologically Effective Copper Peptides Appear to Help Hair Growth.  Left Diagram: At age 15, your scalp is thick and your hair follicles have a rich blood supply (red and blue) and are surrounded by many subcutaneous fat cells (yellow balls) that are felt to enhance the health of the hair follicles. This produces large hair follicles that produce thick shafts of hair.  Center Diagram: As you age and DHT effects set in, your scalp thins, its blood supply is diminished, and the layer of fat cells narrows. This provide less support and nutrition for your hair follicles. This produces smaller follicles that produce thin hair shafts.  Right Diagram: Biologically effective copper peptides help reverse many of these effects. They help re-thicken your scalp, improve the scalp's blood supply, and rebuild subcutaneous fat. This produces a larger follicle that produces thicker hair shafts.

Dr. Pickart invented the copper peptide technology that produced Tricomin and GraftCyte while at ProCyte Corporation, which sells the latter two products. Both GraftCyte for improving the establishment of hair transplants, and Tricomin for stimulating hair growth, have demonstrated efficacy clinical studies.

Many of our customers say that Folligen alone has sufficiently solved their hair problems.

Is Copper Better Than Propecia® for Blocking DHT Production?

Recent research indicates that the DHT that harms hair follicles comes from the the skin's sebocytes and sweat glands (sebaceous glands). (Chen et al 1996)  5 alpha-Reductase, the enzyme system that converts testosterone into DHT occurs in two enzyme forms. The type 1 represents the 'cutaneous type'; it is located primarily in the skin's sebocytes but also in epidermal and follicular keratinocytes, dermal papilla cells and sweat glands as well as in fibroblasts. The type 2 is located mainly in the seminal vesicles, prostate and in the inner root sheath of the hair follicle.

Propecia® (Finasteride), which has a higher affinity for the type 2 form, is best suited for for controlling prostate enlargement. It also must be administered by pills that spread the drug throughout the body.

Copper ion in the skin is more effective in inhibiting the type 1 form which is primarily producing the DHT that damages follicles and can be administered locally to the skin. Sugimoto et al (Sugimito 1995) found that copper ion is a potent inhibitor of 5-alpha reductase, inhibiting both types of 5-alpha reductase (both type 1 and type 2) that produce DHT and is the only metal to do so. Copper ion inhibits (50% reduction in activity) type 1 alpha reductase at 1.9 micromolar (0.12 micrograms copper ion per milliliter) and type 2 alpha reductase at 19.2 microM (1.2 micrograms copper ion per milliliter). No other metal has these effects.

The application of copper-peptides may provide sufficient copper ion into the hair follicle area to block DHT production in the scalp. Metabolically active copper ion (that is, copper ion free to block 5-alpha reductase) in the human body exists at about 1 microgram per milliliter in the blood and less in the skin. While the uptake of ionic copper from copper-peptides applied to the scalp is very low, human experiments by Prof. John Sorenson (University of Arkansas) have found that they can raise copper ion levels in the skin to the effective level of 1 microgram per milliliter.

Calming Actions of Folligen on an Irritated Scalp

Folligen often calms irritated scalp tissue that has been irritated with other hair growth stimulator such as minoxidil or retinoic acid. When using Folligen for scalp calming, start with very light applications of Folligen. On a very irritated scalp, even Folligen can cause a brief stinging, but as your scalp repairs itself, it will become more protective and less sensitive to irritation by minoxidil, retinoic acid, or other items.

Can Folligen Cause Scalp Irritation?

We receive very few reports of scalp irritation. But because any person can have a specific allergy to some ingredient, we recommend starting slowly. Published studies on the copper peptides in Folligen found them to have anti-inflammatory properties on human skin.

Superiority of Folligen Over Other Copper-Peptides

Natural Multiple Stimulators - Folligen is an advanced version of earlier work on copper-peptides and hair follicle regeneration. See www.skinbiology.com/comparingcopperpeptides.html and www.skinbiology.com/copperpeptideregeneration.html. Research on skin and hair follicle renewal indicates that optimal regeneration is obtained only when there are multiple signals for renewal. Folligen contains copper ion plus a mixture of numerous different peptides fragments that are generated by natural proteolytic enzymes (as happens after follicle or scalp damage). This produces numerous copper-peptide complexes in a more natural manner to assist the hair's natural regenerative processes.

Rebuilds Protective Acid Mantle - Folligen rebuilds the protective acid mantle of the scalp that shampoos and conditioners remove. The acid mantle is the combination of sebum (oils) and perspiration, on the skin's surface that protects the skin and renders the skin less vulnerable to damage and attack by environmental factors such as sun and wind and less prone to dehydration. The mantle also has strong anti-oxidant properties and is itself oxidized to protect the skin from oxidation. Sebum is naturally white but air oxidation turns it black (this is why "whitehead comedos" turn into "blackhead comedos").

Normal skin and scalp pH is somewhat acid and in the range of 4.2. to 5.6. It varies from one part of the body to another and, in general, the pH of a man's skin is lower (more acid) than that of a woman's. The acid mantle inhibits the growth of foreign bacteria and fungi and the skin remains healthier, and has fewer blemishes. Acne, allergies and other skin problems become more severe when the skin become more alkaline.

Folligen adjusts the scalp pH into the acid range of optimal scalp health at about pH 5.0. Folligen also contains high levels of lipids such as squalane, cetyl alcohol, glyceryl stearate and stearic acid that closely resembles the fats of the acid mantle. Furthermore, Folligen contains antioxidants such as allantoin, aloe, vitamin E and retinol to aid the mantles protective anti-oxidant properties.

In this manner, Folligen improves scalp health and aids hair growth. Folligen works well with Minoxidil or the Minoxidil and Retinoic Acid combination.

Safety of Folligen - Folligen has passed numerous safety tests at the University of California at San Francisco (UCSF) and at the Shanghai Medical University. Folligen has been found to be non-irritating and safe.  Folligen (1) was non-irritating by the human patch test (5 days of heavy covering of product on the skin), (2) was non-irritating on tape-stripped (injured) human skin, (3) passed the Ames (bacterial) test for carcinogenicity, (4) passed the guinea pig acute skin irritation test and was classified as a non-irritant, (5) passed the human induced-allergy test and classified as a non-allergen, (6) was non-comedogenic in humans and (7) was found have no evidence of oral toxicity in mice.

How Long Will Folligen Last?

A tube of Folligen Cream or Lotion, used 4 times per week, should last about 45 days depending on the size of application area. In our clinical studies, we apply a very light coating (approximately 10 milligrams per square centimeter) to the skin which is then further rubbed into the skin. Folligen Therapy Spray should last 2 to 3 months.

Cautions:

Heavily bleached, very blond hair may pick up a green tint if Folligen is in contact with the hair. Try to keep the products on the scalp. However, many men and women with blond hair report excellent results with the Folligen products. This is similar to the greenish-tint that may occur after spending time in swimming pools.

Too Much Zinc May Damage Your Hair and Speed Aging in Your Body

Copper deficiency in animals causes increased cellular oxidation, increased cancer, increased cardiovascular risk, more atherosclerosis, higher LDL-cholesterol, decreased HDL-cholesterol, more lipid oxidation, aortic aneurysms, osteoarthritis, rheumatoid arthritis, osteoporosis, chronic conditions involving bone and connective tissue, brain defects in newborn, obesity, graying of hair, increased sensitivity to pain, obesity, and reproductive problems. See more below.

In humans, copper deficiency is associated with all of the previous plus depression, impaired brain function, and general fatigue. For more information, please visit www.skinbiology.com/copperhealth.html.

Copper is usually in short supply in the body and high zinc usage drives copper from the body and can produce copper deficiency.
 
 

The effects of topical zinc on hair growth may be due to skin irritation actions. In the 1970's, a number of severe skin irritants, such as nitrobenzene derivatives, were investigated for hair growth properties. While they initially stimulated hair growth, they ultimately produced unacceptable scalp damage and irritation and could not be continued for use.

Zinc salts can inhibit the action of the immune system macrophages on the skin. Since the macrophages are key cell responsible for skin repair,  excessive use of zinc salts on the skin could inhibit skin and hair follicle repair.  Mulhern et al 1986 reported that excessive dietary zinc in mice reduced plasma copper and induced alopecia. Lansdown 1991 (Westminster Medical School, Department of Comparative Biology, London, UK) examined the dermal irritancy of six zinc compounds was examined in three animal models. In open patch tests involving five daily applications, zinc chloride (1% aqueous solution) was severely irritant in rabbit, guinea-pig and mouse tests, inducing epidermal hyperplasia and ulceration; aqueous zinc acetate (20%) was slightly less irritant. Zinc oxide (20% suspension dilute Tween 80), zinc sulphate (1% aqueous solution) and zinc pyrithione (20% suspension) were not overtly irritant, but induced a marginal epidermal hyperplasia and increased hair growth. Thus, hair growth effects observed with zinc may be secondary to dermal irritation. (Lansdown AB, Interspecies variations in response to topical application of selected zinc compounds, Food Chem Toxicol 1991 Jan; 29 (1): 57-64)

Like zinc, topical cortisone has been used to promote hair growth and is often reasonable effective in persons with inflammatory scalp conditions. But cortisone stops skin repair and, if used for an extended period, ultimately thins the skin, damages hair follicles, and causes hair loss.

Products based on GHK-Cu are marketed by AdviCare, American Crew, Amuchina (Europe), Atelier Esthetique, Bard Medical, BioPharm (Middle East), Creative Nail Design, Johnson & Johnson, Schering AG, Neutrogena, Osmotics, ProCyte, Sigmacon Medical Products (Canada) and Tanox Biosystems (Asia). These include products for Cosmetic Skin Renewal: Neutrogena Visibly Firm Night Cream®, Neutrogena Visibly Firm Eye Cream®, Neutrogena Visibly Firm Moisture Makeup®, Neutrogena Visibly Firm Eye Treatment Concealer®, Neutrogena Visibly Face Lotion®, Neutrogena Visibly Firm Body Lotion®, Visibly Firm Face Lotion SPF 20®, Blue Copper Firming Elasticity Repair®, Climate Extreme Body Repair with Copper Peptide®, Simple Solutions Pure Copper Skincare products (Pure Copper Night Renewal®, Pure Copper Morning Dew®, Ultra Copper Firming Serum®, Pure Copper Eye Repair®), Blue Razor Aftershave®, Neova® Eye Therapy, Neova® Night Therapy Creme®, Neova® Day Therapy, Neova® Body Therapy Lotion®, Neova® Cuticle Therapy, Neova® Antioxidant Therapy Serum with GHK Copper Peptide Complex(TM),  Neova® Cuticle Therapy,  Neova® Therapy Cleansing Bar, Neova® Therapy Mattifying Serum, Neova® Therapy Copper Moisture Mask®, Neova® After Shave Therapy and Neova® Body Scrub,  for Veterinary Wound Healing: Iamin-Vet Skin Care Gel® and Iamin-Vet Wound Cleanser®. for Wound Healing: Iamin Gel Wound Dressing®, Iamin Impregnated Gauze Dressing®, Iamin Wet Dressing (copper-saline)®, Iamin-2 Hydrating Gel®, and Iamin Wound Cleanser®; for Hair Transplantation and improving the success of hair transplants: GraftCyte® Advanced Hair Restoration Technology: GraftCyte® Concentrated Spray, GraftCyte® Moist Dressings, GraftCyte® Hydrating Mist, GraftCyte® Post-Surgical Shampoo and Conditioner, and GraftCyte® Head Start Single Patient Pack; for Stimulation of Hair Growth and Hair Vitality: American Crew Revitalize Daily Shampoo®, American Crew Revitalize Spray Solution®, American Crew Revitalize Daily Conditioner®, American Crew Revitalizing Serum®, American Crew Revitalize Daily Moisture Shampoo®;  Tricomin® Solution Follicle Therapy Spray, Tricomin® Revitalizing Shampoo, Tricomin® Restructuring Conditioner and Tricomin® Conditioning Shampoo; and for Post-Surgical Skin Healing after laser resurfacing, dermabrasion, and chemical peels: Complex Cu3® Intensive Repair Cream, Complex Cu3® Hydrating Gel, Complex Cu3® Post Laser Lotion, and Complex Cu3® Gentle Face Cleanser.  In addition, human clinical studies of Pickart's inventions for bone healing and healing of intestinal irritations (Inflammatory Bowel Disease or Crohn's disease) have given positive results. He received his Ph.D. in Biochemistry from the University of California at San Francisco. For details on copper-peptide tissue remodeling - see: www.skinbiology.com/copperpeptideregeneration.html.

Skin Biology is currently patenting and test marketing various products built around his new copper-peptides that are designed to possess greatly enhanced potency, strong breakdown resistance (and can be used with skin exfoliating hydroxy acids for more rapid skin renewal and for scar reduction), a longer duration of action, and very high adherence to skin. The first generation products designed around GHK-Copper performed well in many controlled tests; however, they failed in FDA clinical trials on the healing of difficult-to-heal human wounds. Pickart is of the opinion that this second generation of copper peptides should have a higher chance of success in difficult clinical trials.

Uno and Kurata 1993 -  Uno and Kurata, Chemical agents and peptides affect  hair growth. J Invest Dermatol 1993, 101(1 Suppl):143S-147S

Uno, Packard, Patt 1996 - Uno, Packard, Patt Quantitative Assessment of  Peptide-Copper Complex Induced Hair Follicle Stimulation Using Fuzzy Rat. Dermatological Research Techniques, (CRC Press), pp-227-239, 1996

Sugimito 1995 - Sugimoto Y; Lopez-Solache I; Labrie F; Luu, Cations inhibit specifically type I 5 alpha-reductase found in human skin, J Invest Dermatol 1995 May;104(5):775-8