CP Serum is a water-based lipid-free product. Many clients use CP Serum on oily skin areas such as the T-Zone and Protect & Restore on dryer skin areas. Many users report that it reduces skin oil in the T-Zone.

Often acne is reduced or eliminated by washing the face (as with a pad) with 2% salicylic acid morning and evening and follow this with CP Serum in the evening.

Persons with rosacea often see improvement with CP Serum.

It is at www.skinbio.com/cpserum.htm.

A Safer Day Cover with Skin Remodeling

   Protect & Restore Day Cover is a skin repair cream that helps protect against sunlight (ultraviolet radiation) and environmental pollution. The cream uses many natural absorbers of ultraviolet radiation and does not contain any dangerous sunscreen chemicals. It also can be used under Color Cosmetics to reduce skin damage caused by color cosmetics.

        P&R Day Cover is designed as a daytime replacement for sun protective creams with dangerous chemical sunscreens. This cream contains a high level of natural ultraviolet absorbers such as squalane, peptides, and nucleotides that have been protecting mammalian skin for over 100 million years. In addition, the Day Cover contains titanium dioxide, a safe reflective sun blocker.
 

P&R Day Cover is built around:

    1. Using the skin's natural sun blockers

    2. Using additional safe and reflective titanium dioxide

    3. Including broad spectrum natural anti-oxidants to neutralize oxygen radicals

    4. Helping to rebuild the the skin's acid mantle

    5. Including P&R's clinically-proven skin repair actions

    6. Avoiding the use of irritants, alcohol, and harsh chemicals
 
 

 
 

 

 

 

This is for general use of the body. The lotion helps renew and protect your skin. The product is somewhat similar to P&R Day Cover but is easier to spread and contains no titanium dioxide. It comes in a generous 8 ounce bottle and contains copper-peptides and retinol for skin renewal, plus protective lipids and anti-oxidants. See: http://www.skinbio.com/bodyrenewallotion.html
 
 
 
 
 
 
 

This products have very strong skin repair properties. It is very similar to the strongest copper peptide cream that we had tested in studies at UCSF Dermatology Department.

Rub a very small amount of the cream or serum into scars. Do not over use. The cream is designed to have strong and selective uptake into scars and skin lesions but this may make them more apparent as the copper stains the scars and lesions. So it is best to use this cream at night. Be cautious if using it on your face because of potential staining.

Surprisingly, a number of our clients are using these products for facial care. Super Cop is often used as an eye cream and Super CP Serum over the entire face. But start these products lightly.

See www.scar-reduction.com/supercop.html

ProCyte's Neova and Neutrogena's Visibly Firm

ProCyte Corporation sells a number of gels and creams for skin treatment after laser resurfacing, dermabrasion, and chemical peels such as Neova, Complex Cu3™ Intensive Tissue Repair Creme, Complex Cu3™ Hydrating Gel, and Complex Cu3™ Gentle Face Cleanser. These products are based on the Iamin skin healing technology discovered by Dr. Loren Pickart (who also founded ProCyte Corporation in 1985). This type of product has been shown to have positive effects on collagen deposition, skin tensile strength, angiogenesis, and superoxide dismutase activity.

These products are sold to enhance healing, reduce skin crusting after repair procedures, and help minimize discomfort. The products are applied during the first 24 hours post surgery, and then as needed for the first 10-14 days post procedure.

Neutrogena sells a Visibly Firm product line based on GHK-copper. Neutrogena presented several papers on these creams at the American Academy of Dermatology in 2002. Most of these results were known and published in 1988 by Pickart and colleagues. Summaries of these abstracts are at Copper-Peptide Tissue Regeneration.

P66 A Clinical Evaluation of a Copper-Peptide Containing Liquid Foundation and Cream Concealer Designed for Improving Skin Condition Yohini Appa, PhD; Neutrogena Corporation, Los Angeles, CA; Thomas Stephens, PhD; TJ Stephens & Associates, Inc, Dallas, TX; Sylvia Barkovic; Neutrogena Corporation, Los Angeles, CA; Mary Beth Finkey, MS; Neutrogena Corporation, Los Angeles, CA

P67 The Effect of Tripeptide to Copper Ratio in Two Copper Peptide Creams on Photoaged Facial Skin James J Leyden, MD; University of Pennsylvania, Philadelphia, PA; Gary Grove, PhD; KGL, Inc/Skin Study Center, Broomall, PA; Sylvia Barkovic; Neutrogena Corporation, Los Angeles, CA; Yohini Appa, PhD; Neutrogena Corporation, Los Angeles, CA

P68 Skin Care Benefits of Copper Peptide Containing Facial Cream James J Leyden, MD; University of Pennsylvania, Philadelphia, PA; Thomas Stephens, PhD; Thomas J Stephens & Associates, Inc, Dallas, TX; Mary Beth Finkey, MS; Neutrogena Corporation, Los Angeles, CA; Sylvia Barkovic; Neutrogena Corporation, Los Angeles, CA

P69 Skin Care Benefits of Copper Peptide Containing Eye Creams James J Leyden, MD; University of Pennsylvania, Philadelphia, PA; Thomas Stephens, PhD; Thomas J Stephens & Associates, Inc, Dallas, TX; Mary Beth Finkey, MS; Neutrogena Corporation, Los Angeles, CA; Sylvia Barkovic; Neutrogena Corporation, Los Angeles, CA

P72 Requirement of Copper and Tripeptide Glycyl-L-Histidyl-L-Lysine (GHK) Complex Formation for Collagen Synthesis Activity in Normal Human Dermal Fibroblasts Thierry Oddos, PhD; Johnson & Johnson Consumer, Val de Reuil, France; Aurelie Jumeau-Lafond; Johnson & Johnson Consumer, Val de Reuil, France; Gerd Ries, PhD; Johnson & Johnson, Dusseldorf, Germany

Other Copper Peptides
For more information on these comparisons, please visit www.skinbiology.com/comparingcopperpeptides.html

A clinical study which compared the effect on the skin's production of collagen after using creams containing copper-peptides, vitamin C, or retinoic acid (retin-A) was published by researchers in the Dermatology Department at UMDNJ - Robert Wood Johnson Medical School (Abulghani et al 1998). Twenty volunteers applied the various creams to their thighs daily for one month. New collagen production was determined by studying skin biopsy samples using immunohistological techniques.

The study found, that after one month, copper-peptides had the most significant effect on collagen production. Significant increases in collagen production were found in 70% of the persons treated with copper-peptide creams, 50% of the persons treated with the vitamin C cream, and 40% of the persons treated with retinoic acid.

Significant wrinkle reduction is still difficult. Many products are sold for the reduction of wrinkles but effects are temporary. Keep in mind that a piece of tape on your skin for a day will produce a temporary wrinkle reduction. There have been several successful studies on significant reduction of major wrinkles with retinoic acid. Procyte and Neutrogena have announced successful studies on wrinkle reduction with copper-peptides. There are no published studies on significant wrinkle reduction with vitamin C despite heavy sales of the product for seven years.  

References

Abulghani el al 1998 - Abulghani, Shirin, Morales-Tapia, Sherr, Solodkina, Robertson, and Gottlieb, J. Invest. Derm. 110(4), page 686, 1998.

Alain et al 1999 - Alain, Monier, Emonard, Gillery, Birembaut, Homebeck and Maquart, Expression and activation of matrix metalloproteinases in wounds: Modulation by the tripeptide-copper complex glycyl-l-histidyl-l-lysine-cu2+, J. Invest. Dermat. 112: 957-964.