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Hydrogels for Osteochondral
Tissue Engineering
Journal of Biomedical

(March 2020)
Anti-Wrinkle Activity
& Transdermal Delivery
of GHK Peptide
Journal of Peptide Science
(March 2020)
Pulsed Glow Discharge
to GHK-Cu Determination
International Journal
of Mass Spectrometry

(March 2020)
Protective Effects of GHK-Cu
in Pulmonary Fibrosis
Life Sciences
(January 2020)
Anti-Wrinkle Benefits
of GHK-Cu Stimulating
Skin Basement Membrane
International Journal of Molecular Sciences
(January 2020)
Structural Analysis
Molecular Dynamics of
Skin Protective
TriPeptide GHK
Journal of Molecular Structure
(January 2020)
In Vitro / In Vivo Studies
pH-sensitive GHK-Cu in
Superabsorbent Polymer
GHK Enhances
Stem Cells Osteogenesis
Acta Biomaterialia
Antibacterial GHK-Cu
Nanoparticles for
Wound Healing
Particle & Particle (2019)
Effect of GHK-Cu
on Stem Cells and
Relevant Genes
OBM Geriatrics
GHK Alleviates
Neuronal Apoptosis Due
to Brain Hemorrhage
Frontiers in Neuroscience
Endogenous Antioxidant
International Journal of Pathophysiology and Pharmacology (2018)
Regenerative and
Protective Actions of
GHK-Cu Peptide
International Journal of
Molecular Sciences
Skin Regenerative and
Anti-Cancer Actions
of Copper Peptides
GHK-Cu Accelerates
Scald Wound Healing
Promoting Angiogenesis
Wound Repair and

GHK Peptide Inhibits
Pulmonary Fibrosis
by Suppressing TGF-β1
Frontiers in Pharmacology
Skin Cancer Therapy
with Copper Peptides
The Effect of Human
Peptide GHK Relevant to
Nervous System Function
and Cognitive Decline
Brain Sciences (2017)
Effects of Tripeptide
GHK in Pain-Induced
Aggressive Behavior
Bulletin of Experimental
Biology & Medicine
GHK-Cu Elicits
In Vitro Alterations
in Extracellular Matrix
Am Journal of Respiratory
and Critical Care Medicine

Selected Biomarkers &
Copper Compounds
Scientific Reports

GHK-Cu on Collagen,
Elastin, and Facial Wrinkles
Journal of Aging Science
Tri-Peptide GHK-Cu
and Acute Lung Injury

Effect of GHK Peptide
on Pain Sensitivity
Experimental Pharmacology

New Data of the
Cosmeceutical and
TriPeptide GHK
SOFW Journal
GHK Peptide as a
Natural Modulator of
Multiple Cellular Pathways
in Skin Regeneration
BioMed Research (2015)
Resetting Skin Genome
Back to Health
Naturally with GHK
Textbook of Aging Skin
GHK-Cu May Prevent
Oxidative Stress in Skin
by Regulating Copper and
Modifying Expression of
Numerous Antioxidant Genes Cosmetics (2015)
GHK Increases
TGF-β1 in
Human Fibroblasts

Acta Poloniae

The Human Skin Remodeling Peptide Induces Anti-Cancer
Expression and DNA Repair Analytical Oncology
Resetting the
Human Genome to Health
BioMed Research
Enhanced Tropic Factor Secretion of Mesenchymal
Stem Cells with GHK
Acta Biomater
Anxiolytic (Anti-Anxiety)
Effects of GHK Peptide
Bulletin of Experimental
Biology & Medicine
Lung Destruction and
its Reversal by GHK
Genome Medicine
TriPeptide GHK Induces
Programmed Cell Death
of Neuroblastoma
Journal of Biotechnology
Stem Cell
Recovering Effect
of GHK in Skin
Peptide Science
Skin Penetration of
Copper Tripeptide in Vitro
Journal of International
Inflammation Research
Possible Therapeutics
for Colorectal Cancer
Journal of Clinical and
Experimental Metastasis
Methods of Controlling
Differentiation and
Proliferation of Stem Cells
Effects of
Copper Tripeptide
on Irradiated Fibroblasts
American Medical Association
Avoid Buying Fake Copper Peptides Dangerous














Interview of Dr. Pickart by Jennifer Doyle Published in the Bellevue Club Magazine

Dr. Pickart Skin Care Research

The fabled Fountain of Youth may be just a fantasy, but the discoveries of biochemist Dr. Loren Pickart actually may help mere mortals banish wrinkles, sun damage and other signs of aging.

Through research that began in the 1970s, Loren discovered a revolutionary copper peptide complex that has been shown to help those over age 35 achieve younger-looking skin.

If this sounds like something you'd like to get your hands on, you're not alone.

Loren has founded two companies to develop products that contain this type of copper peptide; in addition, it is available at drugstores in skin-care products made by American Crew, Neutrogena and other cosmetic companies.

Today, his research continues. "One of my goals is to give every woman the skin of a 17-year-old girl," he says.

Loren's interest in medical research took root as a child growing up in the Minnesota heartland.

"When I was 10 years old, I got a serious throat infection that had me in the bed for two weeks," he says. "Then the doctor gave me a shot of penicillin, and I was up and around within the hour."

The idea that the discovery of penicillin could have such a powerful impact on healthcare left a lasting impression on Loren.

As a young adult, he enrolled in the University of Minnesota with the intent of making a career of medical research. After talking to the medical researchers on campus, he decided to concentrate his studies on a relatively new field: human aging.

"This was the '60s, when medical researchers believed they would find a cure for cancer and heart disease in the next 10 years," he says.

"I decided to study human aging instead, because that way I would always have a job."

Once Loren graduated from UM with a degree in chemistry and math, he began working at a gerontological research laboratory in Santa Barbara that studied human aging.

After a few years, he moved to San Francisco to pursue his Ph.D. in biochemistry at the University of California San Francisco.

At UCSF, the research that would dictate his professional life to took shape.

"I was searching for something that would reverse the effects of aging," he explains. "In looking at the blood, I saw that younger blood grows cells better than older blood. The question was, why?" The answer (and subject of Loren's thesis) was a small copper peptide complex that keeps cells alive longer.

Through years of research, working with both UCSF and the University of Washington, Loren discovered that this type of copper peptide has powerful healing and tissue remodeling properties.

In 1980, Loren moved to Bellevue to be closer to the UW Chemistry Department. He founded a biotech company, ProCyte Corporation, to develop what he now calls his "first generation" of copper peptide products.

In several clinical studies set up by Loren, the results were promising: the copper peptide complex was shown to reverse many of the signs of aging, including wrinkles and sun damage.

In 1989, Loren took ProCyte public on NASDAQ. Two years later, tragedy struck. While at the airport during a strenuous business trip, Loren developed a blood clot, a life-threatening condition that required cardiac surgery and extensive rehabilitation.

"I decided to leave ProCyte in order to concentrate on my health," he says.

Today ProCyte is profitable from licensing patented technology and selling its own products ---the Neova line for cosmetic skin renewal, the Complex Cu3 line to improve skin healing after dermatological procedures and Graftcyte for increasing the success of hair transplant grafts.

In 1994, with his health restored, Loren joined with wife Charlene —a UCSF graduate with a master's in mother-infant nursing whom Loren met while attending the university— to form a second biotech company.

"After testing about 200 different copper complexes, I found a special fraction of peptides from soy proteins that possess remarkable skin regeneration properties," he says.

Products built around this second, more effective generation of copper peptides are available.

To date, the market for these products has been largely cosmetic; for example, they are useful for skin recovery after such cosmetic treatments such as skin peels, dermabrasion and laser resurfacing.

Future goals for copper peptide research include developing a product for pre-ulcer dermatitis and, on a larger scale, putting together a complete picture of how the copper peptide works in the human body.

In the meantime, new copper peptide skin creams, exfoliators and acne serums, continue to gain popularity through word of mouth.

"I get calls from 24-year-old models who have heard about our products," says Loren, who adds that those over age 35 will see the most dramatic results.

"Women who start using the skin cream notice that their skin looks better. Then they put it on everything: their faces, hands, feet, husband, children, pets and plants," he quips.

When not searching for ways to restore the perfect peaches-and-cream complexion, Loren can be found traveling with Charlene and their three daughters Germaine, Francoise and Genevieve; enjoying a meal or taking a sauna at the Club; or cruising to the family's vacation home on San Juan Island on his boat, Regenerate.

"I'm 65 years old; I want to enjoy life," he says.

Reflecting on his days at UCSF, he recalls how the university's Biochemistry Department operated with the ideology that one should never do something unless he or she has fun doing it.

Says Loren, "Scientists are like clergymen; they never really retire. I'm lucky that I enjoy what I do."

Questions or Advice?

Email Dr. Loren Pickart:

Call us at 1-800-405-1912 Monday through Friday (8 am to 6 pm) PST